It is also used in the treatment of polycystic ovary syndrome. There were no adverse effects or safety concerns with short term administration although long-term randomized studies are lacking. Because of its positive effects on mood, St. Johns wort has been used to alleviate and naturally remedy PMS symptoms, such as depression, chronic fatigue and hormonal imbalance. Newsletter. It works in a number of ways to decrease the amount of sugar in the blood. Many studies show that St. Johns wort may help fight mild to moderate depression and anxiety and has fewer side effects than most other prescription antidepressants, such as loss of sex drive. I'm also not too happy to find out they put horse urine in them! He is so Hot! All of these are plant-derived estrogens and/or hormones. Cons: Some believe patches are safer than pills however it is too early to know. There is a wide selection of both hormonal and non-hormonal products on the market today to treat vaginal dryness, irritation and painful intercourse. Many women report that the herb works well but it isnt effective for everyone. There are no PMU ranches in the US. Some examples that fall into each of these categories are listed. It is a life full of abuse tossed or aside or killed when they are of no longer of use. Where FDA-approved versions are measured precisely under rigid control, compounded bioidenticals lack these specifications. This plant was fed to goats to improve milk production. The plant has been used for centuries to treat diabetes and the metformin hydrochloride was first isolated from it in 1922. It is sometimes used as an off-label adjunct to lessen the risk of metabolic syndrome in . diarrhea. Drug information provided by: IBM Micromedex. Gels, sprays and creams can rub off before its been fully absorbed so it is necessary to allow them to dry prior to getting dressed. All of these are plant-derived estrogens and/or hormones. To date there are mixed reviews on its effectiveness for some it works, for others it doesnt. See http://www.health.harvard.edu/newsletters/Harvard_Womens_Health_Watch/2011/September/bioidentical-hormones-help-or-hype. A simple search for vaginal dryness on Amazon.com will give you an idea of just how many and what kinds of OTC products are available. Below is an overview of the common types available. St. Johns wort has been used as a medicinal herb for its antidepressant and anti-inflammatory properties for over 2,000 years. Since these forms are absorbed through the skin directly into the bloodstream, its important to prevent people from touching any of these as they will inadvertently get a dose of estrogen as well. The Premarin family of drugs contains estrogenic compounds that are made from the urine of pregnant mares. This includes both FDA-approved and compounded hormones. EPO contains high levels of gamma-linolenic acid (GLA) and linolenic acid, which are both omega-6 fatty acids, known to reduce inflammation. As always, it is important to work with your physician to make an educated decision on what type of HRT would best suit your needs while limiting your risks. Moreover, because it contains coumarins, interactions with warfarin and photosensitization have been reported. It is created by eHealthMe based on reports of 395,495 people who have side effects when . And, as always, please consult with your doctor before you use these or any other alternatives for the relief of menopausal symptoms. Phytoestrogens consist of three main groups: isoflavones, lignans, and coumestans. When you see an ad for any Premarin type product, let us know by using this specialContact Form. Because these products prevent large amounts of estrogen from passing through the rest of the body, as a rule they are considered safer than other forms of HRT and just as importantly do not contain CEEs like Premarin cream does. Examples: Estrace, Cenestin, Enjuvia, Femtrace, Pros: Ease of administration, best-studied. Nutrition: It should go without saying, avoid refined and processed foods, choose more whole foods, fresh fruit, vegetables and complex carbohydrates. However, the longterm efficacy and safety of metformin has not been established in horses. And dont always believe that checking with your doctor is going to help you avoid the Premarin/clone thing. We encourage you to go online to further acquaint yourself with the . As always, it is important to work with your physician to make an educated decision on what type of HRT would best suit your needs while limiting your risks. There are tens of millions of compounded hormone therapy prescriptions a year filled at community and compounding pharmacies for at least 2 billion dollars definitely a money-making business. 1. Answer: Metformin works by decreasing the amount of sugar that the liver produces and the intestines absorb. In other words no prescription drugs used to treat menopausal symptoms, other than the Premarin family, contain pregnant mares urine (this does not include China or other locations outside of the FDAs jurisdiction). Additionally, significant improvements were seen in general, emotional and mental fatigue as well as the occurrence of clinical depression (as expected). . Pregnant mare urine (PMU) is one of the key ingredients in a vast majority of hormone replacement therapy (HRT) drugs, such as Premarin and PremPro. What about the horses used to make pregnant mares urine based drugs? Isoflavones, the soy protein-based group, are most potent of the phytoestrogens and have received the most attention. These are water- or oil-based moisturizers or lubricants that may contain chemicals in some cases. Overall, FDA-approved and compounded bioidenticals contain the same hormones. Metformin has been used in horses to counteract the effects of equine metabolic syndrome. Examples: Divigel (gel), Evavist (spray), Estrace and Estrasorb (vaginal and transdermal creams respectively). These come in a variety of forms, namely; pill, patch, injection, gels, cream (vaginal and skin), vaginal insert, transdermal skin spray, vaginal ring, and vaginal tablet. Other SSRIs that have undergone clinical testing include; Citalopram (Celexa) and Sertraline (Zoloft). More than she will probably ever realize. Vasomotor symptoms (i.e. The mechanism of action is a general term used in medicine to describe how a drug exerts its specific function on the body. Pregnant mare urine (PMU) is one of the key ingredients in a vast majority of hormone replacement therapy (HRT) drugs, such as Premarin and PremPro. The horses are blessed to have such champions in their corner, like you and Jane. And, as always, please consult with your doctor before you use these or any other alternatives for the relief of menopausal symptoms. In pre- and postmenopausal women, estrogens can increase the risk of cancer of the ovaries, stroke, dementia, and serious blood clots in the legs. The vast majority of advocates of BHRT are referring to the compounded versions where hormones are custom-mixed by a pharmacist unapproved drugs. Animals: 4 adult horses. In pre- and postmenopausal women, estrogens can increase the risk of cancer of the ovaries, stroke, dementia, and serious blood clots in the legs. There are many stress-reduction techniques available to manage the burden of everyday anxiety rest, relaxation, varied leisure activities, and most importantly self-affirming thoughts to maintain self-image and confidence. Other medical articles call attention to the same warnings. How? Kind regards, Yvonne. As a woman approaches menopause the levels of estrogen sharply decrease. There are plentiful other non-prescription products available that women with vaginal dryness may find soothing. It also works by decreasing the amount of glucose made by the liver and decreasing the absorption of glucose from the intestine. Those mares are registered Quarter Horses bred to registered Quarter Horse stallions with the exception being some foals are bred to be Warmbloods. Lactulose is found in only certain parts of the milk produced by cows. This plant was fed to goats to improve milk production. For those women who are overweight, weight loss can also help. There is a wealth of information out there, but beware of false claims and err on the side of caution. Doctors are getting pretty free and easy about off-label prescribing this dangerous drug (I say dangerous having read not only the package insert approved/required by the FDA but also some of the research actually available to the public many medical websites are available only by expensive subscription and then only to licensed medical practitioners). hot flashes, night sweats, palpitations) are typically experienced due to reduced estrogen levels and cause sleep disturbances. Examples: Alora, Climara, Estraderrm, Vivelle. The dosage and duration of these medications most appropriate in alleviating hot flashes is unknown; however, regimens using low to moderate dosages seem to be as effective as those using high dosages and have significantly fewer reported adverse effects. SSRIs (selective serotonin reuptakes inhibitors) are a group of anti-depressants and anti-obsessive-compulsives. Reflexology is generally relaxing and may be an effective way to alleviate stress. I'm looking to find one that's coated because it's hard to take bitter pills. Answer: The most common side effects of Metformin are diarrhea nausea and upset stomach. And yes, there are many alternatives for vaginal issues related to menopause that do not contain CEEs (conjugated equine estrogens). There are many stress-reduction techniques available to manage the burden of everyday anxiety rest, relaxation, varied leisure activities, and most importantly self-affirming thoughts to maintain self-image and confidence. There are 26 in Canada that I am aware of. If you elect to take any of the FDA-approved hormone replacement therapies (HRT) the optimum form will depend on your health, your symptoms, personal preference, and what you need to get out of treatment. Stress Management: It is a well-known fact that stress induces more severe hot flashes. Over-the-counter (OTC) products for vaginal dryness can be used intermittently as needed, in-between or in addition to prescription estrogens. Cons: Risks have been well-publicized; increased risk of stroke, blood clot. FDA-approved bioidenticals come with black box warnings analogous to those for conventional HRT. Objective: To determine pharmacokinetics and oral bioavailability of metformin in healthy horses. A very popular medicine, called Premarin, is actually made from horse urine of pregnant mares. It is believed to help influence prostaglandin synthesis and help moderate menopausal symptoms. There have been numerous reports in the medical literature and general media as to the effectiveness of various over-the-counter agents and prescription drugs in reducing menopausal hot flash symptoms. Acting as a natural selective estrogen receptor (ER) modulator, it may also positively affect the cardiovascular system without the harmful estrogenic side effects in breast and uterine tissue. The most common side effects of gabapentin are drowsiness, dizziness, and a spacey feeling. Is the captive bolt a humane death for horses? 2023. It means a lot to us. Everyday when I take Metformin I usually have constipation and the top of my feet are swollen up. Keep up this vital work informing women. Came by the knowledge by pure chance watching old favourite 1990s tv series Millenium starring Lance Hendrikson, season 1, episode 20 called Broken World , I am horrified; man is the cruellist animal . Are blessed to have such champions in their corner, like you and Jane Evavist ( spray ), and... Or any other alternatives for the relief of menopausal symptoms online to further acquaint yourself with the death for?. 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